How Much Do Statins Lower Cholesterol - HealthyCholesterolClub.com (2022)

Are You A Candidate For A Statin

Statins: Side Effects & Alternative Ways to Lower Cholesterol by Dr.Berg

Guidelines from the American College of Cardiology and American Heart Association recommend statin therapy for:

  • Secondary prevention in people with established atherosclerotic cardiovascular disease.
  • People with an LDL cholesterol level of 190 milligrams per deciliter or higher, due to a genetic condition.
  • People with diabetes ages 40 to 75 with an LDL level over 70 mg/dL and no atherosclerotic cardiovascular disease.
  • Non-diabetic adults ages 40 to 75 with a 20% or greater likelihood of developing atherosclerotic cardiovascular disease in the next 10 years .
  • Non-diabetic patients ages 40 to 75 with an LDL level of 70 to 189 mg/dL and a 10-year ASCVD risk of 7.5% to less than 20% if the risk estimate and presence of certain risk-enhancing factors* favor treatment.

* These factors include a family history of ASCVD, LDL levels persistently 160 mg/dL, triglyceride levels persistently 175 mg/dL, chronic kidney disease, ethnicity, inflammatory diseases, metabolic syndrome, and results of high-sensitivity C-reactive protein, lipoprotein, and apolipoprotein B. Note: The guidelines recommend considering coronary artery calcium scoring for people at intermediate risk in whom a decision about starting statin treatment remains uncertain.

Should I Take A Statin If My Cholesterol Is Normal

Yes, no, maybe. It depends on your other risk factors.

Some people still benefit from a statin even if their LDL is ânormal.â For example, you may want to consider statins if you have had a heart attack or you are at high risk for having another heart attack or even a stroke. Also, if you have diabetes and are between 45 and 75 years old, you are at high risk for cardiovascular disease.

In certain people, statins could also help to reduce the risk of heart disease and stroke, even if LDL cholesterol levels are low. For example, if you have high levels of inflammation in your arteries, statins can lower this inflammation and, in turn, lower the risk of cardiovascular disease. This is true even if your cholesterol levels are normal.

Effect On Lomitapide On Lipid And Lipoprotein Levels

The effect of lomitapide on lipid and lipoprotein levels has been studied in patients with Homozygous Familial Hypercholesterolemia. The pivotal study was a 78-week single arm open label study in 29 patients receiving treatment for Homozygous Familial Hypercholesterolemia . Lomitapide was initiated at 5mg per day and was up-titrated to 60mg per day based on tolerability and liver function tests. On an intention to treat basis, LDL-C was decreased by 40% and apolipoprotein B by 39%. In patients who were actually taking lomitapide, LDL-C levels were reduced by 50%. In addition to decreasing LDL-C levels, non-HDL-C levels were decreased by 50%, Lp by 15%, and triglycerides by 45%. Interestingly HDL and apolipoprotein A-I levels were decreased by 12% and 14% respectively in this study. Follow-up revealed that the decrease in LDL-C could be sustained for a prolonged period of time .

The above studies demonstrate that lomitapide decreases LDL-C, non-HDL-C, triglycerides, and Lp levels.

Also Check: How Much Cholesterol In Lobster

Mechanisms Accounting For Bile Acid Sequestrants Induced Lipid Effects

Bile acid sequestrants bind bile acids in the intestine, preventing their reabsorption in the terminal ileum leading to the increased fecal excretion of bile acids . This decrease in bile acid reabsorption reduces the size of the bile acid pool, which stimulates the conversion of cholesterol into bile acids in the liver . This increase in bile acid synthesis decreases hepatic cholesterol levels leading to the activation of SREBPs that up-regulate the expression of the enzymes required for the synthesis of cholesterol and the expression of LDL receptors . The increase in hepatic LDL receptors results in the increased clearance of LDL from the circulation leading to a decrease in serum LDL-C levels . Thus, similar to statins and ezetimibe, bile acids lower plasma LDL-C levels by decreasing hepatic cholesterol levels, which stimulates LDL receptor production and thereby accelerates the clearance of LDL from the blood.

The mechanism by which treatment with bile acid sequestrants improves glycemic control is unclear .

Statins And How Statins Work

How Much Do Statins Lower Cholesterol - HealthyCholesterolClub.com (1)

Doctors also prescribe, usually if lifestyle changes are falling short, drugs like statins. Brand names include Lipitor, Crestor, Mevacor, Pravacol, and Zocor. Statins have been clearly shown to reduce blood cholesterol and prevent atherosclerosis, or heart disease. They work by reducing the livers production of cholesterol. They block an enzyme called HMG CoA Reductase that the liver uses to make cholesterol.

But other things are happening in the liver that statins do not affect. In addition to producing cholesterol, the liver helps clear excess cholesterol from the blood. It has tiny receptors that capture LDL bad cholesterol particles that are floating around. Like vacuum cleaners, these receptors suck this excess cholesterol up and out of the blood, which means theres much less cholesterol seeping into our artery walls, building plaque.

The problem is, a diet full of saturated fats, trans fat, and dietary cholesterol reduces the number and effectiveness of these LDL receptors. And theres nothing statins can do to counteract this process.

Also Check: Is Tuna Good For High Cholesterol

Does Lowering Your Cholesterol Protect You From Ever Having A Heart Attack

Not necessarily. Since their arrival in the 1990s in Americans medicine cabinets nationwide, statin drugs have indeed proven very effective for reducing high LDL levels, and they do slow the progression of cholesterol-filled plaques. But sadly, the #1 cause of death in Americans taking statins to lower their elevated LDL levels is still heart attacks, states Kimberly Gomer, MS, RD, LDN, one of the many faculty who teach wellness education and nutrition workshops at the Pritikin Longevity Center.

Will Statins Increase My Risk For Diabetes Or Complicate My Existing Diabetes

This risk is true to some extent, but its wildly exaggerated.In fact, there are good data to show that people who have problems with their blood sugar or who have diabetes benefit most from statins. Even though their blood sugar may go up slightly, the added risk is significantly offset by the reduction in heart disease risk that a statin can provide.If youre already at risk for developing Type 2 diabetes, or if you have prediabetes, you may monitor your blood glucose more closely after starting a statin. But exercise and weight loss have been shown to lower the risk of developing diabetes in those with borderline blood glucose levels, regardless of statin use.

You May Like: How Much Cholesterol In Pork Chops

What Are The Risks

Before you start taking statins, tell your provider if:

  • You are pregnant, plan to become pregnant, or are breastfeeding. Pregnant and nursing mothers should not take statins.
  • You have allergies to statins.
  • You are taking other medicines.
  • You have diabetes.
  • You have liver disease. You should not take statins if you have certain acute or long-term liver diseases.

Tell your provider about all of your medicines, supplements, vitamins, and herbs. Certain medicines may interact with statins. Be sure to tell your provider before taking any new medicines.

Overall, there is no need to avoid moderate amounts of grapefruit in the diet. An 8 ounce glass or one grapefruit can be safely consumed.

Regular blood tests will help you and your provider:

  • See how well the medicine is working
  • Monitor for side effects, such as liver problems

Questions To Ask Your Doctor

How Statins Work to Reduce Cholesterol

If youâre not sure why your doctor prescribed statins to lower your cholesterol, ask at your next appointment.

  • Why do you think I need a statin?
  • What will it do for me?
  • Based on my specific health, what might I gain from taking one and what are my risks?
  • Could a statin interact with any medicines or supplements Iâm taking?
  • When will I know if this drug is working?
  • Can I take a supplement instead of — or along with — a statin to lower my cholesterol?
  • What supplements or treatments will ease side effects?

Miller tells his patients to look at statins like a daily vitamin to boost health. “In many ways, thatâs what it is,” he says, “and itâs the only one that we know that works so well to improve cholesterol and lower cardiovascular risk.”

Michael Miller, MD, director, the Center for Preventive Cardiology, University of Maryland Medical Center, Baltimore.

Patrick McBride, MD, MPH, director, preventive cardiology program and cholesterol clinic, the University of Wisconsin School of Medicine and Public Health, Madison, Wis.

David Kiefer, MD, assistant clinical professor of medicine, University of Arizona, Tucson.

American Heart Association, Atlanta. Diet and Exercise Key for Treating High Triglycerides: New AHA Statement

Current Opinion in Lipidology, Lowering LDL-Cholesterol Through Diet: Potential Role in the Statin Era, 2011.

Consumer Reports: Heart Supplements: Proceed with Caution.

FDA: “Important safety label changes to cholesterol-lowering statin drugs.”

Don’t Miss: Is Shrimp Bad For Your Cholesterol

What Is The Pritikin Diet

The Pritikin diet significantly reduces saturated fatty acids trans fatty acids , and dietary cholesterol. It also increases dietary fiber in the form of natural, nutrient-rich foods like fruits, vegetables, whole grains, and beans. This is the healthiest way to lower cholesterol, points out cardiologist Ronald Scheib, MD, physician and educator;at the Pritikin Longevity Center in Miami, where the Pritikin Program has been taught since 1975.

Statin Risks And Benefits

Are statins safe? For most people, the answer is a resounding yes,;according to a 2014 Johns Hopkins meta-analysis of 20 years worth of published research. It showed that the risks of long-term use of statin drugs are low and the potential benefits are very high. Researchers combed through hundreds of papers that had studied statins since 1994 to determine the evidence of side effects.

Their review, published in;British Medical Journal,;found an increase in the risk of muscle aches. There was also a modest risk of elevated blood glucose, which can tip some people into developing type 2 diabetes. Whats unclear is whether those people, who also had other risk factors for diabetes, would have developed the condition anyway. Statins dont cause memory loss or cataracts, as has been claimed in the past. For most at-risk patients, the benefits far exceed the risks, the researchers concluded. Of course, if you notice any unusual effects after beginning statin therapy, tell your doctor.

We know a lot about statins because theyve been around for a long time and taken by so many people, Blaha says. The scale clearly tips to benefits in most at-risk patients.

Why did my doctor prescribe statins if my cholesterol is normal?

Read Also: Is Shrimp Bad For Your Cholesterol

Statin Use During A Heart Attack

If youve had a heart attack or are dealing with any other type of acute coronary event, such as interventions like bypass surgery or angioplasty, chances are your physician will prescribe a statin during and immediately after the event, and for good reason. It is generally accepted in the medical community that statins may have some value independent of lowering LDL cholesterol, probably anti-inflammatory in nature.

But doctors do not have clear answers to the following: What statin is best? What dosage? How long should the patient be on it? Usually, high doses are prescribed immediately after the event and are then tapered to doses necessary to maintain target values .

There is much about statins we physicians do not know, states Dr. Ronald Scheib, MD, FACC, FACP, former Chief of Section of Cardiovascular Medicine at the Miami Heart Institute. We do know that toxicity is a clear danger.

Why Have I Been Offered Statins

How Much Do Statins Lower Cholesterol - HealthyCholesterolClub.com (2)

Having a high level of LDL cholesterol is potentially dangerous, as it can lead to a hardening and narrowing of the arteries ;and;cardiovascular disease .

CVD is a general term that describes a disease of the heart or blood vessels. It’s the most common cause of death in the UK.

The main types of CVD are:

  • coronary heart disease;;when the blood supply to the heart becomes restricted
  • angina;;chest pain caused by reduced blood flow to the heart muscles
  • heart attacks;;when the supply of blood to the heart is suddenly blocked
  • stroke;;when the supply of blood to the brain becomes blocked

A doctor may recommend taking statins if either:

  • you have been diagnosed with a form of CVD
  • your personal and family medical history suggests you’re likely to develop CVD at some point over the next 10 years and lifestyle measures have not reduced this risk

Find out more about when statins may be recommended.

Also Check: Are Baked Potatoes High In Cholesterol

What Statins Dont Do

Its also important to keep in mind that statins address just one risk factor for heart disease high cholesterol levels. There are many other risk factors that statins do not touch, like high blood sugar, insulin resistance, belly fat, high blood pressure, and high triglycerides .

To attack all these risk factors, your best bet is a healthy lifestyle like Pritikin, points out Dr. Danine Fruge, Medical Director at Pritikin.

Mechanisms Accounting For The Ezetimibe Induced Lipid Effects

NPC1L1 is highly expressed in the intestine with the greatest expression in the proximal jejunum, which is the major site of intestinal cholesterol absorption . Knock out animals deficient in NPC1L1 have been shown to have a decrease in intestinal cholesterol absorption . Ezetimibe binds to NPC1L1 and inhibits cholesterol absorption . In animals lacking NPC1L1, ezetimibe has no effect on intestinal cholesterol absorption, demonstrating that ezetimibeâs effect on cholesterol absorption is mediated via NPC1L1 . Thus, a major site of action of ezetimibe is to block the absorption of cholesterol by the intestine . Cholesterol in the intestinal lumen is derived from both dietary cholesterol and biliary cholesterol ; thus the majority is derived from the bile . As a consequence, even in patients that have very little cholesterol in their diet, ezetimibe will decrease cholesterol absorption. While ezetimibe is very effective in blocking intestinal cholesterol absorption it does not interfere with the absorption of triglycerides, fatty acids, bile acids, or fat-soluble vitamins including vitamin D and K.

You May Like: Are Mussels High In Cholesterol

Statins Lower Heart Attack Stroke Risk In People At Average Risk

Editors note: This is one in a 10-part series of the top medical research advances of 2016;as determined by the American Heart Association.

Millions more people worldwide may benefit from cholesterol-lowering statins after a global study showed the drugs help reduce heart attacks and strokes in people at moderate risk. The risk fell slightly further when patients also took blood pressure drugs.

Medications to lower blood pressure have been shown to reduce the risk of heart disease in people with elevated blood pressure and those at high risk, and statins have been shown to benefit those at high risk. But a group of researchers wanted to know if treating each condition alone or simultaneously might prevent heart attacks and strokes in an ethnically diverse group of average-risk people without cardiovascular disease.

The study, called Heart Outcomes Prevention Evaluation-3, or HOPE-3, found that the dual low-dose therapy is the best way to reduce cardiovascular risk in older people with elevated blood pressure and nearly normal cholesterol but who had another risk factor such as smoking or obesity. The results were published last April in The;New England Journal of Medicine in three papers, and the research was selected as one of the American Heart Associations top 10 heart and stroke science advances of 2016.

HOPE-3s findings reinforce 2013 guidelines from the AHA and American College of Cardiology that recommend statins for more people.

Mechanism Accounting For The Mipomersen Induced Lipid Effects

Statins and Cholesterol

Apolipoprotein B 100 is the main structural protein of VLDL and LDL and is required for the formation of VLDL and LDL . Familiar Hypobetalipoproteinemia is a genetic disorder due to a mutation of one apolipoprotein B allele that is characterized by very low concentrations of LDL and apolipoprotein B due to the decreased production of lipoproteins by the liver . Mipomersen, an apolipoprotein B antisense oligonucleotide, mimics Familiar Hypobetalipoproteinemia by inhibiting apolipoprotein B 100 production in the liver by pairing with apolipoprotein B mRNA preventing its translation . This decrease in apolipoprotein B synthesis results in a decrease in hepatic VLDL production leading to a decrease in LDL levels.

Read Also: Is Calamari High In Cholesterol

Cholesterol Levels In Dialysis Patients

In a study of dialysis patients, those with higher cholesterol levels had lower mortality than those with low cholesterol.51 Yet the authors claimed that the inverse association of total cholesterol level with mortality in dialysis patients is likely due to the cholesterol-lowering effect of systemic inflammation and malnutrition, not to a protective effect of high cholesterol concentrations. Keeping an eye on further funding opportunities, the authors concluded: These findings support treatment of hypercholesterolemia in this population.

Reducing Heart Disease Naturally

One thing that this study does show is that cardiovascular disease is complicated.

The study also brings to light another fact about cholesterol drugs are not the only way to lower your LDL levels.

Most doctors who prescribe statins for high cholesterol will also recommend that patients exercise more and eat healthier foods.

But more hospitals and doctors offices are starting to promote lifestyle changes as a way for patients to reduce their risk of cardiovascular disease and LDL levels using diet and exercise alone.

Often this approach involves a whole food or plant-based diet rich in vegetables, fruits, whole grains, beans, legumes like chickpeas and lentils, healthy fats like those in olive oil and avocado, and dairy alternatives.

For many, this diet will be a challenge to switch to. But there is a growing body of research on its benefits.

In one

Also Check: How Much Cholesterol Is In Shrimp

Who Needs To Take Statins

In 2018, experts including the AHA and American College of Cardiology released guidelines recommending that doctors prescribe statins to people in the following four high-risk groups:;

  • People who have cardiovascular disease
  • People with a high LDL cholesterol level
  • People who are between 40 and 75 years of age and have type 2 diabetes
  • People between 40 and 75 years of age who have at least a 7.5% risk of getting cardiovascular disease in the next 10 years

Statins are usually prescribed to people who have had a heart attack or stroke, or are at higher risk for having one, such as smokers and people with high blood pressure or diabetes.;

Statins may also be prescribed for people who have high cholesterol levels as a result of genetics. This inherited condition called familial hypercholesterolemia causes some people to produce too much LDL, or bad, cholesterol. Children with FH may also be prescribed statins.

FAQs

How much will 20 mg atorvastatin lower cholesterol? ›

The LDL cholesterol levels of the group receiving 20 mg atorvastatin every day was reduced by %41 by the end of 1 month (p<0.01).

How much can statins lower cholesterol? ›

What are statins? Statins are a type of medicine that are used to lower the cholesterol in your blood, helping to prevent heart disease and stroke. Statins often work very well. They can reduce your LDL cholesterol by around 30%, sometimes even 50% with high doses.

How much will 10 mg of atorvastatin lower cholesterol? ›

A lipid profile was determined as baseline, at 4 weeks and again at 8 weeks. Atorvastatin every other day significantly reduced total cholesterol (TC), triglyceride (TG), and LDL-c versus baseline. The TC, TG, and LDL-c levels were lower by 23 per cent, 8 per cent, and 30 per cent.

How much will 40 mg of atorvastatin lower cholesterol? ›

Results. At 3 and 6 month follow up, Atorvastatin 40 mg leads to mean LDL cholesterol reduction of 47.18 ± 20.81 & 50.03 ± 18.06 respectively. While Atorvastatin 80 mg results in LDL reduction as 50.11 ± 15.85 & 52.30 ± 13.72.

Is 20 mg of atorvastatin a lot? ›

Adults—At first, 10 or 20 milligrams (mg) once a day. Some patients may need to start at 40 mg per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg per day.

Can you stop take statin if your cholesterol is normal? ›

If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.

Do statins clear the arteries of plaque? ›

Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.

What are the negatives of taking statins? ›

Side effects can vary between different statins, but common side effects include:
  • headache.
  • dizziness.
  • feeling sick.
  • feeling unusually tired or physically weak.
  • digestive system problems, such as constipation, diarrhoea, indigestion or farting.
  • muscle pain.
  • sleep problems.
  • low blood platelet count.

What can I take instead of statins to lower cholesterol? ›

7 cholesterol-lowering alternatives to statins
  • Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis. ...
  • Plant stanols and sterols. ...
  • Cholestyramine and other bile acid-binding resins. ...
  • Niacin. ...
  • Policosanol. ...
  • Red yeast rice extract (RYRE) ...
  • Natural products.

What are the most common side effects of atorvastatin 10 mg? ›

Common side effects
  • Feeling sick (nausea) or indigestion. Stick to simple meals and do not eat rich or spicy food. ...
  • Headaches. Make sure you rest and drink plenty of fluids. ...
  • Nosebleeds. ...
  • Sore throat. ...
  • Cold-like symptoms, such as a runny nose, blocked nose or sneezing. ...
  • Constipation or farting (flatulence) ...
  • Diarrhoea.

What is the best statin to lower LDL? ›

Rosuvastatin and atorvastatin are the best at lowering LDL cholesterol.

How much will 10 mg of rosuvastatin lower cholesterol? ›

Rosuvastatin 10 to 40 mg/day caused LDL‐cholesterol decreases of 46% to 55%, when all the trials were combined using the generic inverse variance method. The quality of evidence for these effects is high.

What are the side effects of atorvastatin 40 mg? ›

Side effects of atorvastatin include:
  • Gastrointestinal symptoms such as diarrhea.
  • Cold symptoms such as a runny or stuffy nose.
  • Joint pain.
  • Insomnia.
  • Urinary tract infection.
  • Nausea.
  • Loss of appetite.
  • Indigestion symptoms such as stomach discomfort or pain.

What is the safest statin to take? ›

In relation to renal function, atorvastatin was the safest statin as it resulted in the least number of patients at the end of 2 years of treatment with the new onset of microalbuminuria (10.9%) followed by rosuvastatin (14.3%) and then pravastatin (26.6%).

How quickly does atorvastatin lower cholesterol? ›

Atorvastatin has a rapid onset of action; approximately 90% of the LDL cholesterol reduction from baseline occurred within the first 2 weeks of treatment (Figure).

How long should a person take atorvastatin? ›

How long to take it for. Depending on the reason why you're taking atorvastatin, you may have to take it for a long time, even for the rest of your life. You may want to stop atorvastatin if you think you're having side effects.

What are the long term effects of taking atorvastatin? ›

Clinical studies revealed Lipitor can damage liver function, and the FDA has received rare post-marketing reports of both fatal and nonfatal liver failure. Other reported liver problems include jaundice, hepatitis, chronic liver damage and fatty changes to the liver.

Why do statins have to be taken at night? ›

So, why do people take statins at night? Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.

At what cholesterol level is medication required? ›

Your health care provider may prescribe medicine if: You have already had a heart attack or stroke, or you have peripheral arterial disease. Your LDL cholesterol level is 190 mg/dL or higher.

Will I have to take statins forever? ›

You usually have to continue taking statins for life because if you stop taking them, your cholesterol will return to a high level within a few weeks. If you forget to take your dose, do not take an extra one to make up for it. Just take your next dose as usual the following day.

Are statins worth the risk? ›

Research has shown that statins are highly effective in reducing the risk of fatal heart attack and stroke.

How long does it take for statins to stabilize plaque? ›

Results from clinical trials using carotid ultrasound10,11 and intravascular ultrasound12 and prospective studies using MRI13 suggest that plaque regression can be documented only after at least 1 year of statin therapy.

Can statins cause dementia? ›

No, statins do not increase dementia risk. They may even protect against it. Statins are among the most frequently prescribed medications. Some people taking statins report side effects, including memory loss.

Do statins reduce blood pressure? ›

Conclusion: Statins lower blood pressure by cholesterol-independent mechanisms, and the reduction is larger in individuals with higher blood pressure and those with low HDL-C. Statins may be beneficial in preventing hypertension and may contribute to better blood pressure control in hypertensive patients.

Why do doctors push statins? ›

Statins are among the most commonly prescribed drugs in the U.S. for a reason: They can lower your LDL (low-density lipoproteins) cholesterol (the “bad cholesterol”) by 25% to 50% or more, depending on the specific statin and dose. Statins are also helpful in lowering the risk of heart attack and stroke.

Do statins make you gain weight? ›

Statin use is associated with increased calorie intake and consequent weight gain.

What are the two most common adverse effects of statins? ›

The most common statin side effects include:
  • Headache.
  • Difficulty sleeping.
  • Flushing of the skin.
  • Muscle aches, tenderness, or weakness (myalgia)
  • Drowsiness.
  • Dizziness.
  • Nausea or vomiting.
  • Abdominal cramping or pain.

What is the new treatment for high cholesterol? ›

FDA approves Novartis Leqvio® (inclisiran), first-in-class siRNA to lower cholesterol and keep it low with two doses a year.

What is considered dangerously high cholesterol? ›

A person is considered at high risk for developing heart disease if their total cholesterol level is higher than 240 mg/dL, LDL levels are higher than 160 mg/dL (190 mg/dL is even higher risk), and if the HDL level is below 40 mg/dL.

What reduces cholesterol quickly naturally? ›

Foods that make up a low cholesterol diet can help reduce high levels
  • Oats. ...
  • Barley and other whole grains. ...
  • Beans. ...
  • Eggplant and okra. ...
  • Nuts. ...
  • Vegetable oils. ...
  • Apples, grapes, strawberries, citrus fruits. ...
  • Foods fortified with sterols and stanols.

What should I avoid when taking atorvastatin? ›

A: While taking atorvastatin (Lipitor), avoid high-fat and high-cholesterol foods as part of your overall treatment. You should avoid large quantities of grapefruit or grapefruit juice, which can increase the risk of serious side effects. Also, avoid excess alcohol use, as this may cause serious liver problems.

Do statins make you pee more? ›

Statin Warning Signs

Examples of symptoms that might prompt you to see a doctor include: Excessive thirst or having to urinate frequently.

Does atorvastatin affect sleep? ›

The current evidence, from well-run research trials of more than 100,000 patients, is that statins do not cause insomnia or any other sleep disturbance, compared with a dummy pill (placebo).

How long does it take for oatmeal to lower cholesterol? ›

Oats significantly improved blood cholesterol levels over a period of 4 weeks in a small 2017 study .

What is a healthy cholesterol level by age? ›

Optimal ranges
Age and sexTotal serum cholesterolTriglycerides
all aged 19 years and younger170 mg/dl at mostless than 150 mg/dl
females aged 20 years and older125–200 mg/dlless than 150 mg/dl
males aged 20 years and older125–200 mg/dlless than 150 mg/dl

Which statin raises HDL the most? ›

Between the statins there is a tendency for rosuvastatin to have the greatest effect on both HDL-C and apo A-I. Mean percent changes in HDL-C from baseline across the trials weighted by patient numbers were as follows: rosuvastatin 8.5%, pravastatin 6.5%, simvastatin 6.4%, atorvastatin 5.5%.

Is 5mg of rosuvastatin enough to lower cholesterol? ›

of a 30–40% reduction in LDL-cholesterol for high-risk patients. Indeed, the lowest dose of rosuvastatin that is marketed, 5 mg, reduces LDL-cholesterol by 45% on average, still more than initially necessary for many patients.

Will 5mg of statin lower cholesterol? ›

The data show that rosuvastatin 5 mg is highly effective in lowering LDL-C to recommended levels for most patients (mean reductions ranging from 42 to 52%).

Is 20 mg of rosuvastatin a lot? ›

Adults—At first, 10 to 20 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg. Children—Use and dose must be determined by your doctor.

What does leg pain from statins feel like? ›

Statin-related muscle pain, if it happens at all, usually happens within the first few months after you start the drug or raise the dose. You may feel a constant soreness or weakness in your shoulders, thighs, hips, or calves. If you're like most people, it'll affect both sides of your body equally.

Do statins make arthritis worse? ›

Use of statins is associated with an increased risk of rheumatoid arthritis.

Do statins cause hair loss? ›

Hair loss, or alopecia, is a very rare side effect of all statin drugs. Widely prescribed in the treatment of high cholesterol, statins work by blocking the action of an enzyme the liver uses to make cholesterol. About 1% of people taking statins report hair loss.

What is the safest statin for elderly? ›

Atorvastatin or fluvastatin are usually recommended because there is no need to adjust the dose according to the glomerular filtration rate [28]. In patients without diagnosed atherosclerotic cardiovascular disease, it is indicated a moderate dose of statin, such as atorvastatin 20 mg daily [28].

What level of cholesterol requires statins? ›

Low-density lipoprotein (LDL) cholesterol.

The most important thing your doctor will keep in mind when thinking about statin treatment is your long-term risk of a heart attack or stroke. If your risk is very low, you probably won't need a statin, unless your LDL is above 190 mg/dL (4.92 mmol/L).

Can u take statins every other day? ›

Abstract. Background: Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population.

Do statins clear the arteries of plaque? ›

Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.

How much will 10 mg of atorvastatin lower cholesterol? ›

A lipid profile was determined as baseline, at 4 weeks and again at 8 weeks. Atorvastatin every other day significantly reduced total cholesterol (TC), triglyceride (TG), and LDL-c versus baseline. The TC, TG, and LDL-c levels were lower by 23 per cent, 8 per cent, and 30 per cent.

How much does 20 mg atorvastatin lower cholesterol? ›

The LDL cholesterol levels of the group receiving 20 mg atorvastatin every day was reduced by %41 by the end of 1 month (p<0.01). At the end of three months, the difference between the changes in the all lipid parameters of the two groups was not found to be of statistical significance.

How quickly does atorvastatin lower cholesterol? ›

Atorvastatin has a rapid onset of action; approximately 90% of the LDL cholesterol reduction from baseline occurred within the first 2 weeks of treatment (Figure).

How long does it take for atorvastatin to be effective? ›

It usually takes at least two weeks for Lipitor to start working. High cholesterol is a silent condition that does not usually have symptoms. So, a blood test is the only way to check how well Lipitor is working for you.

How many hours does atorvastatin work? ›

by Drugs.com

It takes about 77 hours (3 days) for atorvastatin to be out of your system. The elimination half life of atorvastatin is approximately 14 hours. This is the time it takes for your body to reduce plasma drug levels by half.

What are the side effects of atorvastatin 20 mg? ›

Side effects of atorvastatin include:
  • Gastrointestinal symptoms such as diarrhea.
  • Cold symptoms such as a runny or stuffy nose.
  • Joint pain.
  • Insomnia.
  • Urinary tract infection.
  • Nausea.
  • Loss of appetite.
  • Indigestion symptoms such as stomach discomfort or pain.

Do statins clear the arteries of plaque? ›

Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.

Why do statins have to be taken at night? ›

So, why do people take statins at night? Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.

What can I take instead of statins to lower cholesterol? ›

7 cholesterol-lowering alternatives to statins
  • Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis. ...
  • Plant stanols and sterols. ...
  • Cholestyramine and other bile acid-binding resins. ...
  • Niacin. ...
  • Policosanol. ...
  • Red yeast rice extract (RYRE) ...
  • Natural products.

What is the most serious side effect of atorvastatin? ›

Serious side effects

Stop taking atorvastatin and contact 111 or call your doctor if: you get unexplained muscle pain, tenderness, weakness or cramps – these can be signs of muscle breakdown and kidney damage.

What should I avoid when taking atorvastatin? ›

A: While taking atorvastatin (Lipitor), avoid high-fat and high-cholesterol foods as part of your overall treatment. You should avoid large quantities of grapefruit or grapefruit juice, which can increase the risk of serious side effects. Also, avoid excess alcohol use, as this may cause serious liver problems.

How long does it take for oatmeal to lower cholesterol? ›

Oats significantly improved blood cholesterol levels over a period of 4 weeks in a small 2017 study .

Does atorvastatin affect sleep? ›

The current evidence, from well-run research trials of more than 100,000 patients, is that statins do not cause insomnia or any other sleep disturbance, compared with a dummy pill (placebo).

What should be monitored when taking atorvastatin? ›

Patients starting atorvastatin should have liver function tests and a lipid panel performed at baseline, with a repeat lipid panel after six weeks on therapy. Liver function tests should be repeated as clinically indicated. Once the patient is stable, lipids can be checked every 6 to 12 months.

Can you stop taking statins Once you start? ›

If you've been taking statins and would like to stop, you'll need to do so with your doctor's guidance. This is because it can be dangerous to stop taking statins. These drugs are highly effective in preventing heart problems such as heart attack and stroke.

Are statins worth the risk? ›

Research has shown that statins are highly effective in reducing the risk of fatal heart attack and stroke.

Do statins make you pee more? ›

Statin Warning Signs

Examples of symptoms that might prompt you to see a doctor include: Excessive thirst or having to urinate frequently.

What does leg pain from statins feel like? ›

Statin-related muscle pain, if it happens at all, usually happens within the first few months after you start the drug or raise the dose. You may feel a constant soreness or weakness in your shoulders, thighs, hips, or calves. If you're like most people, it'll affect both sides of your body equally.

You might also like

Latest Posts

Article information

Author: Duncan Muller

Last Updated: 08/25/2022

Views: 5880

Rating: 4.9 / 5 (79 voted)

Reviews: 94% of readers found this page helpful

Author information

Name: Duncan Muller

Birthday: 1997-01-13

Address: Apt. 505 914 Phillip Crossroad, O'Konborough, NV 62411

Phone: +8555305800947

Job: Construction Agent

Hobby: Shopping, Table tennis, Snowboarding, Rafting, Motor sports, Homebrewing, Taxidermy

Introduction: My name is Duncan Muller, I am a enchanting, good, gentle, modern, tasty, nice, elegant person who loves writing and wants to share my knowledge and understanding with you.